Scientific Reports, 2016, 6, pp.30817. ⟨10.1038/srep30817⟩
We aimed to determine whether moderate diet restriction could restore cardiac, oxidative and metabolic alterations induced by postnatal overfeeding (PNOF). Litters of C57BL/6 male mice were either maintained at 9 (normal litter, NL), or reduced to 3 (small litter, SL) in order to induce PNOF. At 6 months, half of the NL and SL mice were subjected to 20% calorie-restriction (CR: NLCR, SLCR) for one month, while the other half continued to eat ad libitum (AL: NLAL, SLAL). Six-month old SL mice presented overweight, fat accumulation, hyperleptinemia, glucose intolerance, insulin resistance, increased cardiac ROS production and decreased left ventricular ejection fraction (LVEF). After CR, SL mice body weight was normalized; however, their fat mass and leptinemia were not decreased, glucose metabolism was improved and LVEF was increased. In SL mice, CR increased the cardiac mitochondrial respiratory rate and decreased cardiac ROS production. Hearts from SLCR mice showed better recovery and smaller postischemic infarct size. Intriguingly, no difference was observed between NLAL and NLCR mice for most of the parameters investigated. Short-term moderate CR not only normalized body weight in SL mice but also improved metabolic programming and reversed oxidative and cardiac dysfunction induced by PNOF.
Na Li, Charles Guenancia, Eve Rigal, Olivier Hachet, Pauline Chollet, et al.. Short-term moderate diet restriction in adulthood can reverse oxidative, cardiovascular and metabolic alterations induced by postnatal overfeeding in mice. Scientific Reports, 2016, 6, pp.30817. ⟨10.1038/srep30817⟩ (lien externe). ⟨hal-01431722⟩ (lien externe)
Citations
APA
Li, N., Guenancia, C., Rigal, E., Hachet, O., Chollet, P., Desmoulins, L., Leloup, C., Rochette, L., & Vergely, C. (2016). Short-term moderate diet restriction in adulthood can reverse oxidative, cardiovascular and metabolic alterations induced by postnatal overfeeding in mice. In Scientific Reports. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964358
MLA
Li, Na, et al. “Short-Term Moderate Diet Restriction in Adulthood Can Reverse Oxidative, Cardiovascular and Metabolic Alterations Induced by Postnatal Overfeeding in Mice.” Scientific Reports, July 2016, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964358.
Chicago
Li, Na, Charles Guenancia, Eve Rigal, Olivier Hachet, Pauline Chollet, Luc Desmoulins, Corinne Leloup, Luc Rochette, and Catherine Vergely. 2016. “Short-Term Moderate Diet Restriction in Adulthood Can Reverse Oxidative, Cardiovascular and Metabolic Alterations Induced by Postnatal Overfeeding in Mice.” Scientific Reports. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964358.
Harvard
Li, N. et al. (2016) “Short-term moderate diet restriction in adulthood can reverse oxidative, cardiovascular and metabolic alterations induced by postnatal overfeeding in mice,” Scientific Reports. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964358.
ISO 690
LI, Na, GUENANCIA, Charles, RIGAL, Eve, HACHET, Olivier, CHOLLET, Pauline, DESMOULINS, Luc, LELOUP, Corinne, ROCHETTE, Luc and VERGELY, Catherine, 2016. Short-term moderate diet restriction in adulthood can reverse oxidative, cardiovascular and metabolic alterations induced by postnatal overfeeding in mice [en ligne]. July 2016. Disponible à l'adresse : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964358