Fully Automated Electrophysiological Model Personalisation Framework from CT Imaging

There has been a recent growing interest for cardiac computed tomography (CT) imaging in the electrophysiological community. This imaging modality indeed allows to locate and assess post-infarct scar heterogeneity, allowing to predict zones of abnormal electrical activity and even personalise EP models. To this end, most of the literature uses manually segmented CT images where one fundamental information is extracted, the myocardial wall thickness. In this paper, we evaluate the impact of using an automated deep learning (DL) methodology to segment the left ventricular wall and extract relevant scar information on the resulting personalised models. Using CT images from 8 patients that were not used during the DL training, we show that the automated segmentation is very similar to the manual one (median Dice score: 0.9). Thickness information obtained this way is also very close to the manual one (median difference: 0.7 mm). A wavefront propagation model personalisation framework based on this thickness information does not show relevant differences in its output (median difference in local activation time: 2 ms), proving its robustness. Bipolar electrograms, simulated through a novel approach, do not differ significantly between manual and automated segmentations (Pearson's r: 0.99).

Nicolas Cedilnik, Josselin Duchateau, Frederic Sacher, Pierre Jaïs, Hubert Cochet, et al.. Fully Automated Electrophysiological Model Personalisation Framework from CT Imaging. FIMH 2019 - 10th International Conference on Functional Imaging and Modeling of the Heart, Jun 2019, Bordeaux, France. pp.325-333. ⟨hal-02106609⟩ (lien externe)