Sex Differences in Outcomes of Tetralogy of Fallot Patients With Implantable Cardioverter-Defibrillators

JACC: Clinical Electrophysiology2022Victor Waldmann, Abdeslam Bouzeman, Guillaume Duthoit, Linda Koutbi, Francis Bessière, Fabien Labombarda, Christelle Marquié, Jean-Baptiste Gourraud, Pierre Mondoly, Jean Marc Sellal, Pierre Bordachar, Alexis Hermida, Alain Al Arnaout, Frédéric Anselme, Caroline Audinet, Yvette Bernard, Serge Boveda, Sok Sithikun Bun, Morgane Chassignolle, Gaël Clerici, Antoine da Costa, Maxime de Guillebon, Pascal Defaye, Nathalie Elbaz, Romain Eschalier, Rodrigue Garcia, Charles Guenancia, Benoit Guy-Moyat, Franck Halimi, Didier Irles, Laurence Iserin, François Jourda, Magalie Ladouceur, Philippe Lagrange, Mikael Laredo, Jacques Mansourati, Grégoire Massoulié, Amel Mathiron, Philippe Maury, Anne Messali, Kumar Narayanan, Cédric Nguyen, Sandro Ninni, Marie-Cécile Perier, Bertrand Pierre, Penelope Pujadas, Frédéric Sacher, Pascal Sagnol, Ardalan Sharifzadehgan, Camille Walton, Pierre Winum, Cyril Zakine, Laurent Fauchier, Raphaël Martins, Jean Luc Pasquié, Jean-Benoit Thambo, Xavier Jouven, Nicolas Combes, Eloi Marijon

JACC: Clinical Electrophysiology, 2022, 8 (10), pp.1304-1314. ⟨10.1016/j.jacep.2022.06.024⟩

Background: Women with congenital heart disease at high risk for sudden cardiac death have been poorly studied thus far.Objectives: The aim of this study was to assess sex-related differences in patients with tetralogy of Fallot (TOF) and implantable cardioverter-defibrillators (ICDs).Methods: Data were analyzed from the DAI-T4F (French National Registry of Patients With Tetralogy of Fallot and Implantable Cardioverter Defibrillator) cohort study, which has prospectively enrolled all patients with TOF with ICDs in France since 2010. Clinical events were centrally adjudicated by a blinded committee.Results: A total of 165 patients (mean age 42.2 ± 13.3 years) were enrolled from 40 centers, including 49 women (29.7%). Among the 9,692 patients with TOF recorded in the national database, the proportion of women with ICDs was estimated to be 1.1% (95% CI: 0.8%-1.5%) vs 2.2% (95% CI: 1.8%-2.6%) in men (P < 0.001). The clinical profiles of patients at implantation, including the number of risk factors for ventricular arrhythmias, were similar between women and men. During a median follow-up period of 6.8 years (IQR: 2.5-11.4 years), 78 patients (47.3%) received at least 1 appropriate ICD therapy, without significant difference in annual incidences between women (12.1%) and men (9.9%) (HR: 1.22; 95% CI: 0.76-1.97; P = 0.40). The risk for overall ICD-related complications was similar in women and men (HR: 1.33; 95% CI: 0.81-2.19; P = 0.30), with 24 women (49.0%) experiencing at least 1 complication.Conclusions: Our findings suggest that women with TOF at high risk for sudden cardiac death have similar benefit/risk balance from ICD therapy compared with men. Whether ICD therapy is equally offered to at-risk women vs men warrants further evaluation in TOF as well as in other congenital heart disease populations. (French National Registry of Patients With Tetralogy of Fallot and Implantable Cardioverter Defibrillator [DAI-T4F]; NCT03837574)

Victor Waldmann, Abdeslam Bouzeman, Guillaume Duthoit, Linda Koutbi, Francis Bessière, et al.. Sex Differences in Outcomes of Tetralogy of Fallot Patients With Implantable Cardioverter-Defibrillators. JACC: Clinical Electrophysiology, 2022, 8 (10), pp.1304-1314. ⟨10.1016/j.jacep.2022.06.024⟩ (lien externe). ⟨hal-03825249⟩ (lien externe)

Citations

APA

Waldmann, V., Bouzeman, A., Duthoit, G., Koutbi, L., Bessière, F., Labombarda, F., Marquié, C., Gourraud, J.-B., Mondoly, P., Sellal, J. M., Bordachar, P., Hermida, A., Al Arnaout, A., Anselme, F., Audinet, C., Bernard, Y., Boveda, S., Bun, S. S., Chassignolle, M., … Marijon, E. (2022). Sex Differences in Outcomes of Tetralogy of Fallot Patients With Implantable Cardioverter-Defibrillators. In JACC: Clinical Electrophysiology. https://dx.doi.org/10.1016/j.jacep.2022.06.024

MLA

Waldmann, Victor, et al. “Sex Differences in Outcomes of Tetralogy of Fallot Patients With Implantable Cardioverter-Defibrillators.” JACC: Clinical Electrophysiology, Jan. 2022, https://dx.doi.org/10.1016/j.jacep.2022.06.024.

Chicago

Waldmann, Victor, Abdeslam Bouzeman, Guillaume Duthoit, Linda Koutbi, Francis Bessière, Fabien Labombarda, Christelle Marquié, et al. 2022. “Sex Differences in Outcomes of Tetralogy of Fallot Patients With Implantable Cardioverter-Defibrillators.” JACC: Clinical Electrophysiology. https://dx.doi.org/10.1016/j.jacep.2022.06.024.

Harvard

Waldmann, V. et al. (2022) “Sex Differences in Outcomes of Tetralogy of Fallot Patients With Implantable Cardioverter-Defibrillators,” JACC: Clinical Electrophysiology. Available at: https://dx.doi.org/10.1016/j.jacep.2022.06.024.

ISO 690

WALDMANN, Victor, BOUZEMAN, Abdeslam, DUTHOIT, Guillaume, KOUTBI, Linda, BESSIÈRE, Francis, LABOMBARDA, Fabien, MARQUIÉ, Christelle, GOURRAUD, Jean-Baptiste, MONDOLY, Pierre, SELLAL, Jean Marc, BORDACHAR, Pierre, HERMIDA, Alexis, AL ARNAOUT, Alain, ANSELME, Frédéric, AUDINET, Caroline, BERNARD, Yvette, BOVEDA, Serge, BUN, Sok Sithikun, CHASSIGNOLLE, Morgane, CLERICI, Gaël, DA COSTA, Antoine, DE GUILLEBON, Maxime, DEFAYE, Pascal, ELBAZ, Nathalie, ESCHALIER, Romain, GARCIA, Rodrigue, GUENANCIA, Charles, GUY-MOYAT, Benoit, HALIMI, Franck, IRLES, Didier, ISERIN, Laurence, JOURDA, François, LADOUCEUR, Magalie, LAGRANGE, Philippe, LAREDO, Mikael, MANSOURATI, Jacques, MASSOULIÉ, Grégoire, MATHIRON, Amel, MAURY, Philippe, MESSALI, Anne, NARAYANAN, Kumar, NGUYEN, Cédric, NINNI, Sandro, PERIER, Marie-Cécile, PIERRE, Bertrand, PUJADAS, Penelope, SACHER, Frédéric, SAGNOL, Pascal, SHARIFZADEHGAN, Ardalan, WALTON, Camille, WINUM, Pierre, ZAKINE, Cyril, FAUCHIER, Laurent, MARTINS, Raphaël, PASQUIÉ, Jean Luc, THAMBO, Jean-Benoit, JOUVEN, Xavier, COMBES, Nicolas and MARIJON, Eloi, 2022. Sex Differences in Outcomes of Tetralogy of Fallot Patients With Implantable Cardioverter-Defibrillators [en ligne]. January 2022. Disponible à l'adresse : https://dx.doi.org/10.1016/j.jacep.2022.06.024

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